منابع مشابه
Homology modeling in a dynamical world.
A key concept in template-based modeling (TBM) is the high correlation between sequence and structural divergence, with the practical consequence that homologous proteins that are similar at the sequence level will also be similar at the structural level. However, conformational diversity of the native state will reduce the correlation between structural and sequence divergence, because structu...
متن کاملthird world intellectuals in v. s. naipaul’s fiction: the mimic men, a bend in the river, magic seeds
this thesis attempts to study the representations of the third-world intellectuals in three fictional works by the british-educated trinidadian nobel-winner v. s. naipaul: the mimic men, a bend in the river, and magic seeds. the first one recounts the story of ralph singh’s sense of alienation, his experiences as a colonial politician, and his struggle to give order to his disorderly world thro...
15 صفحه اولIn silico Homology Modeling and Epitope Prediction of NadA as a Potential Vaccine Candidate in Neisseria meningitidis
Neisseria meningitidis is a facultative pathogen bacterium which is well founded with a number of adhesion molecules to facilitate its colonization in human nasopharynx track. Neisseria meningitidis is a major cause of mortality from sever meningococcal disease and septicemia. The Neisseria meningitidis adhesion, NadA, is a trimeric autotransporter adhesion molecule which is involved in cell ad...
متن کاملComparison of the Lipophosphoglycan 3 Gene of the Lizard and Mammalian Leishmania: A Homology Modeling
Background: Lipophosphoglycan 3 (LPG3) is required for the LPG assembly, a well known virulent molecule. In this study, the LPG3 gene of the lizard and mammalian Leishmania species were cloned and sequenced. A three-dimensional structure (3D) for the target sequence was also predicted by comparative (homology) modeling. Materials and Methods: An optimization PCR amplification was performed o...
متن کاملSequence Matching in Homology Modeling
Homology-based modeling, or more simply homology modeling, is becoming increasingly important. Models accurate to within 1-2 Å RMS deviation from the actual three-dimensional structure can be produced by homology modeling in favorable cases. With the number of known threedimensional structures projected to grow to more than ten thousand structures by the end of the decade, it will be possible t...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2017
ISSN: 0961-8368
DOI: 10.1002/pro.3274